Description

2H-Cyclopenta[b]furan-2-one, 5-[[(1,1-diMethylethyl)diMethylsilyl]oxy]-4-[3-[[(1,1-diMethylethyl)diMethyl silyl]oxy]-5-Methyl-1-nonenyl]hexahydro-, [3aa,4a(1E,3S*,5S*),5b,6aa]- is a sophisticated, high-value organosilicon-protected intermediate featuring a complex, stereodefined molecular architecture. Its primary value lies in serving as a critical chiral building block for the synthesis of complex natural products and bioactive molecules, where precise stereochemistry is paramount. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors who require high-purity, specialty intermediates for complex synthetic routes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the total synthesis of prostaglandins, leukotrienes, and other bioactive prostanoid analogs.
• Agrochemical Synthesis: Used in the research and development of novel, stereospecific pesticides and plant growth regulators.
• Advanced Material Precursor: Serves as a building block for liquid crystals, specialty polymers, and other functional materials requiring specific molecular geometry.
• Organic Synthesis Research: A valuable tool for methodological development in stereoselective synthesis, including asymmetric cyclization and carbon-carbon bond formation reactions.
• Process Chemistry: Employed in scaling up routes to complex target molecules for clinical trial material (CTM) and commercial Active Pharmaceutical Ingredient (API) manufacturing.
• Academic & Institutional Research: Used in university and institutional labs for cutting-edge research in synthetic organic chemistry and medicinal chemistry.

Basic Information

Item	Details
Product Name	2H-Cyclopenta[b]furan-2-one, 5-[[(1,1-diMethylethyl)diMethylsilyl]oxy]-4-[3-[[(1,1-diMethylethyl)diMethyl silyl]oxy]-5-Methyl-1-nonenyl]hexahydro-, [3aa,4a(1E,3S*,5S*),5b,6aa]-
CAS No.	149585-88-6
Molecular Formula	C30H58O4Si2
Molecular Weight	538.96 g/mol
Synonyms	(3aα,4α(1E,3S*,5S*),5β,6aα)-5-[(tert-Butyldimethylsilyl)oxy]-4-[3-[(tert-butyldimethylsilyl)oxy]-5-methyl-1-nonenyl]hexahydro-2H-cyclopenta[b]furan-2-one; Corey Lactone TBS Diol Derivative; TBS-protected Corey Lactone Intermediate; Stereoisomer of Prostaglandin Intermediate; tert-Butyldimethylsilyl (TBS) Ether of a Corey Lactone Diol; Protected Bicyclic Lactone Intermediate; CAS 149585-88-6
EINECS	Contact for details

Quality Control

Every batch of this high-purity intermediate is produced and analyzed under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to ensure exacting standards for identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the primary container to prevent degradation. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de (diastereomeric excess)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.