Description

5-[2,4-dioxo-5-[3-[2-[2-[2-[2-[2-[2-[6-[6-[5-(7-oxo-3-thia-6,8-diazabicyclo[3.3.0]oct-2-yl)pentanoylamino]hexanoylamino]hexanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]prop-1-ynyl]pyrimidin-1-yl]-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid is a sophisticated, high-purity nucleotide analog derivative designed for advanced research and development. This compound is critical for applications requiring precise molecular conjugation and labeling, particularly in the development of novel therapeutics and diagnostic probes. It is primarily utilized by pharmaceutical R&D teams and biotechnology companies focused on oligonucleotide synthesis, targeted drug delivery systems, and cutting-edge molecular biology.

Application

• Oligonucleotide Synthesis: As a modified phosphoramidite or intermediate for introducing specialized functional groups into DNA/RNA sequences.
• Probe Development: For creating highly sensitive and specific labeled probes used in diagnostic assays, including qPCR and FISH.
• Drug Discovery: Serving as a key building block in the research and development of antisense oligonucleotides, siRNA, and other nucleic acid-based therapeutics.
• Bioconjugation: Enabling the site-specific attachment of oligonucleotides to proteins, peptides, antibodies, or nanoparticles for targeted delivery and imaging.
• Chemical Biology Research: Used as a tool compound to study nucleic acid interactions, enzyme mechanisms, and cellular processes.
• Diagnostic Kit Manufacturing: Incorporated into the production of high-performance in-vitro diagnostic (IVD) components.

Basic Information

Product Name	5-[2,4-dioxo-5-[3-[2-[2-[2-[2-[2-[2-[6-[6-[5-(7-oxo-3-thia-6,8-diazabicyclo[3.3.0]oct-2-yl)pentanoylamino]hexanoylamino]hexanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]prop-1-ynyl]pyrimidin-1-yl]-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid
CAS No.	145396-04-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-5-[N-(trifluoroacetylaminohexyl)-3-acrylimido]-uridine-3'-[2-cyanoethyl-N,N-diisopropylphosphoramidite]; Custom Nucleotide Derivative; Modified dU Phosphoramidite; Aminohexylacrylamide-dU CE Phosphoramidite; 5-(3-Acrylimido-1-hexylcarbamoyl)-2'-deoxyuridine derivative; Oligonucleotide Modification Reagent; Nucleic Acid Conjugation Reagent
EINECS	Contact for details

Quality Control

Our production of this high-value nucleotide derivative adheres to stringent GMP-grade principles for research materials. Every batch undergoes comprehensive analytical characterization, including HPLC for purity verification and MS and NMR for structural confirmation. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting purity, identity, and critical quality attributes to ensure batch-to-batch consistency and reliability for your sensitive applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under anhydrous conditions. This material is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in anhydrous acetonitrile, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.