Description

[(2S,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-[[(2R,3R,4S,6S)-3,4-dihydroxy-6-methyl-5-oxo-oxan-2-yl]oxy-hydroxy-phosphoryl]oxy-phosphinic acid is a high-purity nucleotide derivative of significant interest in advanced biochemical research and pharmaceutical development. Its complex structure makes it a critical intermediate for synthesizing novel nucleoside analogs and exploring enzyme inhibition mechanisms. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors focused on antiviral, anticancer, and metabolic disorder therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel nucleoside-based active pharmaceutical ingredients (APIs) for antiviral and anticancer drugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate metabolic pathways, particularly those involving nucleotide kinases and polymerases.
• Pro-drug Development: Employed in the design and synthesis of nucleotide pro-drugs to enhance cellular uptake and therapeutic efficacy.
• Diagnostic Reagent Synthesis: Acts as a precursor for labeled nucleotides used in diagnostic assays and molecular biology kits.
• Life Science Tools: Incorporated into the development of specialized reagents for cell signaling and metabolism research.

Basic Information

Product Name	[(2S,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-[[(2R,3R,4S,6S)-3,4-dihydroxy-6-methyl-5-oxo-oxan-2-yl]oxy-hydroxy-phosphoryl]oxy-phosphinic acid
CAS No.	18186-48-6
Molecular Formula	C16H23N5O16P2
Molecular Weight	603.32 g/mol
Synonyms	Adenosine 5'-(trihydrogen diphosphate), 2'-(1-methyl-1,2-ethanediyl) ester, 5'→5'-ester with 1,4-dihydro-1-β-D-ribofuranosyl-3-pyridinecarboxamide; 1,4-Dihydro-1-β-D-ribofuranosyl-3-pyridinecarboxamide, 5'→5'-ester with adenosine 5'-(trihydrogen diphosphate), 2'-(1-methyl-1,2-ethanediyl) ester; NADH, reduced nicotinamide adenine dinucleotide (analog); Diphosphopyridine nucleotide, reduced (analog); Coenzyme I, reduced (analog); Nicotinamide adenine dinucleotide, reduced (structural analog); Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this nucleotide derivative adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity suitable for research and development. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to minimize moisture condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.