Description

S-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (E)-hex-2-enethioate is a sophisticated, high-purity biochemical intermediate of significant interest in advanced pharmaceutical research and development. This compound is critical for its role as a modified nucleotide analog, enabling targeted studies in enzymology and cellular signaling pathways. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and biotechnology companies focused on developing novel therapeutic agents and diagnostic tools.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the synthesis of novel nucleotide-based therapeutics, including potential antiviral and anticancer agents.
• Biochemical Assay Development: Used as a substrate or inhibitor in enzymatic studies to investigate the mechanisms of kinases, polymerases, and other nucleotide-processing enzymes.
• Proteomics and Signal Transduction Research: Employed in studies exploring post-translational modifications and intracellular signaling cascades where nucleotide cofactors play a role.
• Diagnostic Reagent Manufacturing: Acts as a critical component in the formulation of high-sensitivity diagnostic kits and assays for research use.
• Academic Research: Utilized in university laboratories for fundamental research in biochemistry, molecular biology, and medicinal chemistry.
• Pre-clinical Drug Discovery: Integral to hit-to-lead optimization and mechanism-of-action studies for new chemical entities.

Basic Information

Item	Details
Product Name	S-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (E)-hex-2-enethioate
CAS No.	10018-93-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Adenosine 5'-(tetrahydrogen triphosphate), 2'-deoxy-; dATP derivative; Modified deoxyadenosine triphosphate analog; Nucleotide-thioester conjugate; Biochemical research intermediate; ATP analog, S-modified; (E)-Hex-2-enethioate derivative of dATP; Research biochemical 10018-93-6
EINECS	Contact for details

Quality Control

Our production of this high-value biochemical adheres to strict quality management systems. Each batch is characterized using advanced analytical techniques including HPLC, LC-MS, and NMR to ensure structural identity and purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profile, and analytical results. Quality standards are aligned with the requirements for research and pre-clinical grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, Methanol (limited)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.