Description

1H-Imidazole, 1-Ethyl-2-(Trimethylsilyl)- is a specialized organosilicon derivative of the imidazole heterocycle. This compound is valued as a key synthetic intermediate and protecting group reagent in advanced organic synthesis. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those containing functionalized imidazole cores.
• Agrochemical Synthesis: Used in the research and development of new fungicides, herbicides, and plant growth regulators where the silylated imidazole moiety imparts specific biological activity or stability.
• Organometallic Catalyst Ligand: Acts as a precursor or ligand in the development of transition metal catalysts for cross-coupling and other catalytic transformations.
• Silyl Protecting Group Reagent: The trimethylsilyl (TMS) group is utilized to protect sensitive functional groups during multi-step synthetic sequences, with the imidazole acting as a leaving group.
• Materials Science Research: Employed in the synthesis of organic semiconductors, ionic liquids, or metal-organic frameworks (MOFs) that incorporate nitrogen-rich heterocyclic components.
• Chemical Biology Probes: Useful for modifying biomolecules or creating tagged compounds for studying biological mechanisms and interactions.

Basic Information

Product Name	1H-Imidazole, 1-Ethyl-2-(Trimethylsilyl)-
CAS No.	960412-61-7
Molecular Formula	C8H16N2Si
Molecular Weight	168.31 g/mol
Synonyms	1-Ethyl-2-(trimethylsilyl)-1H-imidazole; 2-(Trimethylsilyl)-1-ethylimidazole; 1-Ethyl-2-trimethylsilylimidazole; N-Ethyl-2-(trimethylsilyl)imidazole; 1-Ethyl-2-TMS-imidazole; 2-TMS-1-ethylimidazole; 960412-61-7
EINECS	Contact for details

Quality Control

Our 1H-Imidazole, 1-Ethyl-2-(Trimethylsilyl)- is produced under strict quality management protocols. Each batch undergoes comprehensive analytical characterization, including NMR, HPLC, and GC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your R&D and quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.