Description

Panobinostat Lactate is a potent and selective histone deacetylase (HDAC) inhibitor, specifically formulated as the lactate salt to enhance its stability and handling properties. This compound is a critical active pharmaceutical ingredient (API) for advanced oncology research and therapeutic development. It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in the development of novel cancer treatments, particularly for hematological malignancies.

Application

• Pharmaceutical API: Serves as the key active ingredient in the formulation of finished dosage forms for clinical and commercial use.
• Oncology Research: Used extensively in preclinical and clinical research to study its mechanisms of action against various cancer cell lines.
• Drug Development: A vital component in the development pipeline for new HDAC inhibitor-based therapies and combination treatments.
• Biochemical Research: Employed as a tool compound in epigenetics research to investigate histone acetylation and gene expression regulation.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	Panobinostat Lactate
CAS No.	960055-56-5
Molecular Formula	C21H23N3O2 • C3H6O3
Molecular Weight	349.41 (free base) / 441.49 (lactate salt approx.)
Synonyms	LBH589 Lactate; Panobinostat (Lactate); N-Hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide Lactate; Farydak (Lactate); (2E)-N-Hydroxy-3-[4-({[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enamide 2-hydroxypropanoate
EINECS	Contact for details

Quality Control

Our Panobinostat Lactate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods, to ensure it meets stringent pharmaceutical-grade specifications. Certificates of Analysis (COA) documenting full compliance with release specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single unknown impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.