Description

Tetrahydro-3',5'-Dichloromethotrexate is a key chemical intermediate, primarily recognized for its role in the synthesis of more complex pharmaceutical compounds. Its value lies in its specific chlorinated tetrahydrofolate structure, which is crucial for developing targeted therapeutic agents. This product is essential for research institutions and pharmaceutical manufacturers engaged in the development of novel antimetabolites and chemotherapeutic candidates.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of advanced methotrexate analogs and related chemotherapeutic agents.
• Biochemical Research: Used in studies investigating folate metabolism, enzyme inhibition (e.g., dihydrofolate reductase), and structure-activity relationships (SAR).
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Precursor for Labeled Compounds: Acts as a starting material for the synthesis of deuterated or radiolabeled versions for pharmacokinetic and metabolic studies.

Basic Information

Product Name	Tetrahydro-3',5'-Dichloromethotrexate
CAS No.	17700-70-8
Molecular Formula	C₂₀H₂₃Cl₂N₈O₅
Molecular Weight	502.35 g/mol
Synonyms	3',5'-Dichloro-5,6,7,8-tetrahydro-methotrexate; NSC 139490; 5,6,7,8-Tetrahydro-3',5'-dichloromethotrexate; 3',5'-Dichlorotetrahydro-methotrexate; (2S)-2-[[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]amino]-5-[(3,5-dichlorophenyl)amino]-5-oxopentanoic acid
EINECS	Contact for details

Quality Control

Our Tetrahydro-3',5'-Dichloromethotrexate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets exacting standards for research and synthesis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.