Description

Temozolomideacid CAS NO 113942-30-6 is a key pharmaceutical intermediate and impurity standard in the synthesis of the potent alkylating agent Temozolomide. Its precise chemical structure is critical for ensuring the efficacy and purity of the final active pharmaceutical ingredient (API). This compound is essential for manufacturers and research institutions focused on oncology drug development and quality control. It serves as a vital building block and reference material for producing high-purity Temozolomide, a frontline treatment for glioblastoma multiforme and other malignancies.

Application

• Primary Pharmaceutical Intermediate: Used in the multi-step synthesis of the anticancer drug Temozolomide (TMZ).
• Reference Standard for Impurity Profiling: Acts as a critical analytical standard in HPLC and LC-MS methods to identify and quantify related substances in Temozolomide API.
• Process Development & Research: Employed in R&D for optimizing synthetic routes, scaling up production, and developing new formulations of Temozolomide.
• Quality Assurance/Quality Control (QA/QC): Essential for pharmaceutical QC laboratories to verify the identity and purity of Temozolomide batches against pharmacopeial standards (USP, EP).
• Academic and Clinical Research: Utilized in studies investigating the metabolism, mechanism of action, and resistance profiles of Temozolomide.

Basic Information

Product Name	Temozolomideacid
CAS No.	113942-30-6
Molecular Formula	C6H6N6O2
Molecular Weight	194.15 g/mol
Synonyms	3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid; Temozolomide Acid; Temozolomide Impurity; Temozolomide Carboxylic Acid; TMZ Acid; NSC 362856; CCRIS 9387; Imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid, 3-methyl-4-oxo-3,4-dihydro-
EINECS	Contact for details

Quality Control

Our Temozolomideacid is manufactured under strict quality systems suitable for pharmaceutical intermediate applications. We provide material that typically meets high-purity standards, supported by comprehensive analytical testing. A Certificate of Analysis (COA) is supplied with each batch, detailing key parameters such as assay, purity by HPLC, and identification. Specifications can be aligned with client requirements for research, development, or cGMP manufacturing needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 99.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.