Description

Amonafide n-Oxide is a key chemical intermediate and research compound of significant interest in pharmaceutical development. Its primary value lies in its role as a derivative and potential metabolite of the anticancer agent Amonafide, making it a critical reference standard and building block for advanced research. This compound is essential for researchers and manufacturers in the fields of oncology drug discovery, metabolite identification, and analytical method development. High-purity Amonafide n-Oxide is fundamental for ensuring the accuracy and reliability of pharmacokinetic and toxicological studies.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and qualification of Amonafide and its metabolites in biological matrices.
• Oncology Research: Serves as a crucial intermediate in the synthesis and study of novel topoisomerase II inhibitors and related anticancer agents.
• Metabolite Synthesis & Study: Employed in the synthesis of oxidative metabolites for pharmacological and toxicological profiling during drug development.
• Analytical Method Development: Acts as a standard for developing and validating HPLC, LC-MS, and other chromatographic assays in quality control and bioanalytical labs.
• Biochemical Research: Utilized in mechanistic studies to understand the biotransformation pathways and activity of naphthalimide-based compounds.
• Process Chemistry: Functions as a high-purity intermediate in the scale-up and optimization of active pharmaceutical ingredient (API) manufacturing processes.

Basic Information

Product Name	Amonafide n-Oxide
CAS No.	112726-97-3
Molecular Formula	C16H17N3O3
Molecular Weight	299.33 g/mol
Synonyms	5-Amino-2-[2-(dimethylamino)ethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione 2-Oxide; Amonafide N-Oxide; Amonafide Metabolite; 1H-Benz[de]isoquinoline-1,3(2H)-dione, 5-amino-2-[2-(dimethylamino)ethyl]-, 2-oxide; UNII-9V6A2E6W4S; 9V6A2E6W4S; Amonafide Oxide
EINECS	Contact for details

Quality Control

Our Amonafide n-Oxide is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure it meets the high-purity standards required for pharmaceutical research and development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to stringent internal quality standards to ensure batch-to-batch consistency and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.