Description

4-Borono-D-Phenylalanine B10 Enriched is a specialized, isotopically enriched analog of the amino acid phenylalanine, where the boron-10 isotope is incorporated into the boronic acid functional group. This compound is critical for Boron Neutron Capture Therapy (BNCT), an advanced, targeted binary radiotherapy for treating certain cancers. It is primarily required by pharmaceutical researchers, radiopharmaceutical manufacturers, and advanced medical institutions developing next-generation oncology treatments.

Application

• Boron Neutron Capture Therapy (BNCT): As a key boron delivery agent for the targeted treatment of malignant tumors such as glioblastoma and head & neck cancers.
• Pharmaceutical Research & Development: For the synthesis and study of novel boron-containing drug candidates and targeted radiopharmaceuticals.
• Isotope-Labeled Compound Synthesis: Serving as a building block for creating other B10-enriched molecules for research and diagnostic applications.
• Preclinical & Clinical Studies: Utilized in biodistribution, pharmacokinetic, and efficacy studies related to BNCT protocols.
• Amino Acid Transporter Research: Used as a probe to study the function and expression of L-type amino acid transporters (LAT1) in cancer cells.
• Reference Standard: Acting as a high-purity analytical standard for quality control in the production of BNCT agents.

Basic Information

Item	Details
Product Name	4-Borono-D-Phenylalanine B10 Enriched
CAS No.	111821-49-9
Molecular Formula	C9H12B10NO4
Molecular Weight	209.01 g/mol (for B10 isotope)
Synonyms	BPA; Boronophenylalanine; L-BPA; 4-Dihydroxyboryl-D-phenylalanine; B10-BPA; D-4-Boronophenylalanine; BNCT Agent BPA; p-Boronophenylalanine; (2R)-2-Amino-3-(4-boronophenyl)propanoic acid
EINECS	Contact for details

Quality Control

Every batch of 4-Borono-D-Phenylalanine B10 Enriched is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, isotopic enrichment, and absence of critical impurities, meeting the stringent requirements for pharmaceutical and research applications. A detailed Certificate of Analysis (COA) including HPLC purity, chiral purity, boron-10 isotopic enrichment, and residual solvent analysis is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Boron-10 Isotopic Enrichment	≥ 95.0 atom %
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.