Description

cis-3-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Cyclobutanemethanol is a high-value, organosilicon-protected cyclobutane derivative, serving as a critical chiral building block in advanced organic synthesis. Its primary value lies in providing a sterically hindered, silyl-protected hydroxyl group on a strained cyclobutane ring, enabling precise stereochemical control in complex molecule construction. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for synthesizing novel active ingredients and complex natural product analogs.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of novel small-molecule therapeutics, including protease inhibitors and receptor modulators.
• Agrochemical Synthesis: Building block for creating advanced herbicides, fungicides, and insecticides with specific stereochemical requirements.
• Material Science Research: Precursor for synthesizing monomers or ligands used in polymer chemistry and catalyst design.
• Asymmetric Synthesis: Employed in stereoselective reactions, such as cross-couplings and cycloadditions, to introduce the cyclobutane moiety.
• Natural Product Analog Synthesis: Used to construct the core cyclobutane structure found in certain terpenoids and other bioactive natural products.
• Process Chemistry & Scale-up: Suitable for development from laboratory-scale research to pilot-scale production under GMP-like conditions.

Basic Information

Product Name	cis-3-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Cyclobutanemethanol
CAS No.	959749-93-0
Molecular Formula	C11H24O2Si
Molecular Weight	216.40 g/mol
Synonyms	cis-3-((tert-Butyldimethylsilyl)oxy)cyclobutanemethanol; (1r,3s)-3-((tert-Butyldimethylsilyl)oxy)cyclobutanemethanol; cis-3-(TBDMS-oxy)cyclobutanemethanol; TBDMS-protected cis-3-hydroxycyclobutanemethanol; Cyclobutanemethanol, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, cis-; (cis)-3-((tert-Butyldimethylsiloxy))cyclobutanemethanol
EINECS	Contact for details

Quality Control

Every batch of cis-3-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Cyclobutanemethanol is manufactured and tested under strict quality management systems to ensure identity, purity, and consistency. Our standard pharmaceutical intermediate grade is characterized by comprehensive analytical methods including HPLC, GC, NMR, and chiral analysis. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support development projects with custom purity grades and analytical packages upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.