Description

3-(1-Adamantyl)-1-Phenyl-1H-Pyrazole-4-Carbonyl Chloride is a high-value, functionalized heterocyclic building block featuring both an adamantyl group and an acid chloride moiety. This compound matters as a critical intermediate for synthesizing advanced pharmaceutical and agrochemical agents, enabling the introduction of lipophilic, bulky adamantane scaffolds known to enhance metabolic stability and binding affinity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in antiviral, neurological, and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of new-generation pesticides and herbicides, where the adamantyl group can improve environmental persistence and efficacy.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers with unique thermal and mechanical properties.
• Chemical Biology & Proteomics: Utilized as a reactive handle for labeling or modifying biomolecules in probe development and bioconjugation strategies.
• Organic Synthesis & Catalysis: Acts as a versatile substrate in coupling reactions and for constructing complex molecular architectures in academic and industrial research.

Basic Information

Product Name	3-(1-Adamantyl)-1-Phenyl-1H-Pyrazole-4-Carbonyl Chloride
CAS No.	959033-82-0
Molecular Formula	C20H21ClN2O
Molecular Weight	340.85 g/mol
Synonyms	1-Adamantyl-3-phenyl-1H-pyrazole-4-carbonyl chloride; 3-(1-Adamantyl)-1-phenyl-4-pyrazolecarbonyl chloride; 1H-Pyrazole-4-carbonyl chloride, 3-(1-adamantyl)-1-phenyl-; 3-(Tricyclo[3.3.1.13,7]dec-1-yl)-1-phenyl-1H-pyrazole-4-carbonyl chloride; Adamantyl Phenyl Pyrazole Carbonyl Chloride; CAS 959033-82-0
EINECS	Contact for details

Quality Control

Our 3-(1-Adamantyl)-1-Phenyl-1H-Pyrazole-4-Carbonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request, supporting compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) and separated from strong bases and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.