Description

Diphenylacetyl Chloride is a versatile and highly reactive organic acid chloride intermediate. Its primary value lies in its role as a key building block for the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and manufacturers requiring a reliable precursor for amide and ester formation, peptide coupling, and the introduction of the diphenylacetyl moiety. Industries such as pharmaceuticals, fine chemicals, and advanced material science utilize this reagent for developing active ingredients and specialty compounds.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of active pharmaceutical ingredients (APIs), including potential neuroprotective agents and enzyme inhibitors.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators.
• Peptide Chemistry: Serves as a coupling agent or protecting group reagent in the synthesis of modified peptides and peptidomimetics.
• Fine Chemical Production: Key intermediate for manufacturing dyes, pigments, and specialty polymers requiring the diphenylacetyl group.
• Material Science Research: Employed in the development of novel organic frameworks, liquid crystals, and advanced polymeric materials.
• Academic & R&D: A valuable reagent for methodological development in organic synthesis and medicinal chemistry research.

Basic Information

Product Name	Diphenylacetyl Chloride
CAS No.	1871-76-7
Molecular Formula	C14H11ClO
Molecular Weight	230.69 g/mol
Synonyms	2,2-Diphenylacetyl Chloride; α-Phenylbenzeneacetyl Chloride; Diphenylacetic Acid Chloride; (Diphenylacetyl) Chloride; DPA-Cl; NSC 404083; 2,2-Diphenylethanoyl Chloride; Diphenyl Chloroacetate (common misnomer)
EINECS	217-500-6

Quality Control

Our Diphenylacetyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Production adheres to cGMP guidelines where applicable, and all materials are fully traceable. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with major regulatory frameworks including REACH, and can provide documentation for pharmaceutical (USP/EP) or technical grade specifications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and reacts violently with water, strong bases, and alcohols. Containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation from moisture and to maintain purity. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Diphenylacetic Acid	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.