Description

4-Acetylbenzenesulfonyl Chloride is a versatile and reactive aromatic sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in its dual functional groups, which allow for selective modification to create complex molecules with tailored properties. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based drugs, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Dyestuff and Pigment Manufacturing: Acts as an intermediate for producing sulfonated azo dyes and other colorants.
• Polymer Chemistry: Employed in the synthesis of specialty polymers and resins, such as sulfonated poly(ether ether ketone) (SPEEK) for membrane applications.
• Chemical Research & Development: A valuable reagent for constructing molecular libraries and exploring new chemical entities in medicinal chemistry.
• Ligand and Catalyst Preparation: Used to synthesize sulfonated ligands for metal complexes in catalytic processes.

Basic Information

Product Name	4-Acetylbenzenesulfonyl Chloride
CAS No.	1788-10-9
Molecular Formula	C8H7ClO3S
Molecular Weight	218.66 g/mol
Synonyms	p-Acetylbenzenesulfonyl Chloride; 4-Acetylphenylsulfonyl Chloride; 1-(4-Chlorosulfonylphenyl)ethanone; 4-Acetylbenzenesulphonyl Chloride; 4-Acetylbenzene-1-sulfonyl Chloride; p-Acetylphenylsulfonyl Chloride; Ethanone, 1-[4-(chlorosulfonyl)phenyl]-
EINECS	217-246-6

Quality Control

Our 4-Acetylbenzenesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	92 - 96 °C
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.