Description

1-(5-Chloro-2-Fluorophenyl)Ethan-1-Ol is a high-purity fluorinated and chlorinated aromatic alcohol, serving as a critical chiral building block in advanced organic synthesis. Its unique structure provides a versatile handle for introducing specific stereochemistry and functional groups into complex target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel therapeutic agents, including central nervous system (CNS) drugs and anti-inflammatory compounds.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging the fluorine and chlorine substituents for enhanced bioactivity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated aromatic components for electronic display materials and organic light-emitting diodes (OLEDs).
• Asymmetric Catalysis Research: Employed as a standard substrate or ligand precursor in the development and screening of new chiral catalysts.
• Fine Chemical Production: Acts as a versatile intermediate for custom synthesis and the manufacture of specialty chemicals with specific optical activity.
• Academic & Industrial R&D: Utilized in methodological studies and scale-up process development for new synthetic routes involving halogenated aromatic alcohols.

Basic Information

Product Name	1-(5-Chloro-2-Fluorophenyl)Ethan-1-Ol
CAS No.	958653-04-8
Molecular Formula	C8H8ClFO
Molecular Weight	174.60 g/mol
Synonyms	1-(5-Chloro-2-fluorophenyl)ethanol; α-Methyl-5-chloro-2-fluorobenzyl alcohol; (5-Chloro-2-fluorophenyl)methylcarbinol; 2-Fluoro-5-chloro-α-methylbenzyl alcohol; 1-(5-Chloro-2-fluorophenyl)ethyl alcohol; (RS)-1-(5-Chloro-2-fluorophenyl)ethan-1-ol; 958653-04-8; 5-Chloro-2-fluoro-α-methylbenzyl alcohol
EINECS	Contact for details

Quality Control

Every batch of 1-(5-Chloro-2-Fluorophenyl)Ethan-1-Ol is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with stringent internal specifications, which are aligned with industry best practices for advanced pharmaceutical intermediates. A detailed Certificate of Analysis (COA) providing purity, chiral purity (enantiomeric excess), and impurity profile data is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its sensitivity to oxidation, long-term storage under an inert atmosphere (e.g., nitrogen or argon) is recommended for optimal stability. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e. (or as specified)
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.