Description

(R)-(-)-α-(Trifluoromethyl)Benzyl Alcohol is a high-value, optically active chiral building block characterized by its trifluoromethyl and benzyl alcohol functional groups. This compound matters significantly in advanced organic synthesis, where its stereochemistry and fluorine content are leveraged to modulate the biological activity, metabolic stability, and physicochemical properties of target molecules. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, as well as by fine chemical manufacturers producing specialized intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and production of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Synthesis: Used in developing advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances lipophilicity and bioactivity.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty monomers and polymers with unique surface properties.
• Fluorine Chemistry Studies: A valuable compound for academic and industrial research into the effects of fluorination on molecular properties.

Basic Information

Product Name	(R)-(-)-α-(Trifluoromethyl)Benzyl Alcohol
CAS No.	10531-50-7
Molecular Formula	C8H7F3O
Molecular Weight	176.14 g/mol
Synonyms	(R)-1-Phenyl-2,2,2-trifluoroethanol; (R)-α-(Trifluoromethyl)benzyl alcohol; (R)-(-)-1-Phenyl-2,2,2-trifluoroethanol; (R)-TFB; (R)-TFE; (R)-(-)-TFPE; (R)-2,2,2-Trifluoro-1-phenylethanol; (R)-Trifluoromethylphenylcarbinol
EINECS	Contact for details

Quality Control

Our (R)-(-)-α-(Trifluoromethyl)Benzyl Alcohol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting standards for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.