Description

1-[4-(Trifluoromethoxy)Phenyl]Ethan-1-Ol is a high-value fluorinated aromatic alcohol building block, prized for its unique trifluoromethoxy substituent which imparts enhanced lipophilicity and metabolic stability to target molecules. This compound is essential for the synthesis of advanced intermediates in pharmaceutical and agrochemical research, where its structural motif is leveraged to fine-tune biological activity and physicochemical properties. It is primarily sought after by R&D chemists and process development scientists in the life sciences and specialty chemical sectors.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in CNS and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances bioactivity.
• Liquid Crystal Materials: Serves as a precursor in the production of fluorinated liquid crystals for advanced display technologies.
• Organic Electronic Materials: Employed in the synthesis of charge-transport or emissive materials for OLEDs and other electronic applications.
• Cross-Coupling Reactions: A versatile substrate for Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Asymmetric Synthesis: Used as a chiral alcohol component or resolved to produce enantiomerically pure intermediates for stereoselective synthesis.

Basic Information

Product Name	1-[4-(Trifluoromethoxy)Phenyl]Ethan-1-Ol
CAS No.	1737-28-6
Molecular Formula	C9H9F3O2
Molecular Weight	206.16 g/mol
Synonyms	1-(4-(Trifluoromethoxy)phenyl)ethanol; 4-(Trifluoromethoxy)phenethyl alcohol; α-Methyl-4-(trifluoromethoxy)benzenemethanol; 1-[4-(Trifluoromethoxy)phenyl]ethanol; p-(Trifluoromethoxy)phenethyl alcohol; (4-Trifluoromethoxyphenyl)ethanol; 2-[4-(Trifluoromethoxy)phenyl]ethan-1-ol (common misassignment); TFMPE
EINECS	Contact for details

Quality Control

Our 1-[4-(Trifluoromethoxy)Phenyl]Ethan-1-Ol is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding research and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.