Description

5-[[7-[3-[Ethyl[2-(Phosphonooxy)Ethyl]Amino]Propoxy]-4-Quinazolinyl]Amino]-n-(3-Fluorophenyl)-1H-Pyrazole-3-Acetamide (2Z)-2-Butenedioate (1:1) is a high-purity, non-salt form of a sophisticated quinazoline derivative, specifically designed for advanced research and development. This compound is of significant interest in pharmaceutical discovery due to its potential as a key intermediate or active pharmaceutical ingredient (API) targeting specific kinase pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in oncology and inflammatory disease research. Our supply ensures consistent quality and reliable availability for critical preclinical and process development work.

Application

• Pharmaceutical Research & Development (R&D): Serves as a critical intermediate or reference standard in the synthesis and optimization of novel drug candidates, particularly kinase inhibitors.
• Preclinical Studies: Used in in vitro and in vivo studies to investigate biological activity, pharmacokinetics, and mechanism of action.
• Process Chemistry & Scale-Up: Acts as a starting material or advanced intermediate for process route development and optimization towards Good Manufacturing Practice (GMP) production.
• Analytical Method Development: Employed as a high-purity standard for developing and validating analytical methods such as HPLC, LC-MS, and NMR for quality control.
• Chemical Biology Probes: Can be utilized to create tool compounds for studying specific cellular signaling pathways and target engagement.
• Reference Material: Provides a certified material for comparative analysis and quality assurance in regulatory filings.

Basic Information

Product Name	5-[[7-[3-[Ethyl[2-(Phosphonooxy)Ethyl]Amino]Propoxy]-4-Quinazolinyl]Amino]-n-(3-Fluorophenyl)-1H-Pyrazole-3-Acetamide (2Z)-2-Butenedioate (1:1)
CAS No.	957104-91-5
Molecular Formula	C30H35FN7O7P • C4H4O4
Molecular Weight	Contact for details
Synonyms	5-[[7-[3-[Ethyl[2-(Phosphonooxy)ethyl]amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-1H-pyrazole-3-acetamide (2Z)-2-butenedioate (1:1); Fumarate salt of a quinazoline kinase inhibitor intermediate; (2Z)-2-Butenedioic acid compound with 5-[[7-[3-[ethyl[2-(phosphonooxy)ethyl]amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-1H-pyrazole-3-acetamide (1:1); CAS 957104-91-5.
EINECS	Contact for details

Quality Control

Every batch of 5-[[7-[3-[Ethyl[2-(Phosphonooxy)Ethyl]Amino]Propoxy]-4-Quinazolinyl]Amino]-n-(3-Fluorophenyl)-1H-Pyrazole-3-Acetamide (2Z)-2-Butenedioate (1:1) is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency that meet the exacting standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.