Description

Gdc-0941 Bimesylate is a potent and selective small-molecule inhibitor of phosphatidylinositol 3-kinase (PI3K), specifically targeting the alpha and delta isoforms. This compound is a critical research tool for investigating the PI3K/AKT/mTOR signaling pathway, which is a central regulator of cell growth, proliferation, and survival, and is frequently dysregulated in cancers. It is primarily utilized by pharmaceutical researchers, medicinal chemists, and biologists in preclinical drug discovery and development for oncology and other therapeutic areas.

Application

• Biochemical Research: Used as a reference standard and tool compound for in vitro studies of PI3K signaling mechanisms and enzyme kinetics.
• Cell-Based Assays: Employed to inhibit PI3K activity in cell culture models to study downstream effects on apoptosis, proliferation, and metabolism.
• Preclinical Oncology Research: Serves as a lead compound or benchmark in the development of novel PI3K-targeted anticancer therapeutics.
• Pharmacology Studies: Utilized in animal models to evaluate the pharmacokinetics, efficacy, and toxicity profiles of PI3K inhibition.
• Signal Transduction Analysis: A key reagent for dissecting the role of specific PI3K isoforms in various disease pathways beyond cancer, such as immunology and inflammation.

Basic Information

Product Name	Gdc-0941 Bimesylate
CAS No.	957054-33-0
Molecular Formula	C23H27N5O3S • 2(CH4O3S)
Molecular Weight	Contact for details
Synonyms	GDC-0941 Bimesylate; Pictilisib Bimesylate; GDC0941 Bimesylate; 2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)piperazin-1-yl]methyl]thieno[3,2-d]pyrimidin-4-amine bismethanesulfonate; RG-7321 Bimesylate
EINECS	Contact for details

Quality Control

Our Gdc-0941 Bimesylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.