Description

Pictilisib CAS NO 957054-30-7 is a potent, selective, and ATP-competitive small-molecule inhibitor of phosphatidylinositol 3-kinase (PI3K), specifically targeting the p110α isoform. This compound is a critical research tool for investigating the PI3K/Akt/mTOR signaling pathway, which is frequently dysregulated in cancer and metabolic diseases. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in oncology drug discovery and preclinical studies.

Application

• Oncology Research: A key biochemical tool for studying the role of PI3K signaling in tumor cell proliferation, survival, and angiogenesis.
• Drug Discovery & Development: Used as a reference standard and a lead compound in the development of novel targeted cancer therapies.
• Mechanistic Studies: Enables the exploration of pathway crosstalk and resistance mechanisms in various cancer cell lines and animal models.
• Biomarker Research: Assists in identifying predictive biomarkers for PI3K inhibitor sensitivity or resistance.
• Combination Therapy Studies: Investigated in preclinical models for potential synergistic effects with other chemotherapeutic or targeted agents.
• Signal Transduction Analysis: Used to dissect the complex PI3K pathway in metabolic, cardiovascular, and inflammatory disease research.

Basic Information

Product Name	Pictilisib
CAS No.	957054-30-7
Molecular Formula	C₂₄H₂₈N₈O₂
Molecular Weight	460.54 g/mol
Synonyms	GDC-0941; 2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)piperazin-1-yl]methyl]-8-morpholin-4-yl-1,3-benzothiazin-4-one; Pictilisib free base; GDC 0941; GDC0941; PI3K inhibitor GDC-0941
EINECS	Contact for details

Quality Control

Our Pictilisib is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research and development purposes. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, and specifications can be provided to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a controlled, dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.