Description

[(2S,6R)-6-{N2-Isobutyryl-Guanin-9-Yl}-4-Tritylmorpholin-2-Yl]Methyl Dimethylphosphoramide Chloridate is a sophisticated nucleoside phosphoramidite monomer, a critical building block in the automated synthesis of oligonucleotides. Its primary value lies in enabling the precise, large-scale production of modified DNA and RNA sequences for advanced research and therapeutic applications. This high-purity intermediate is essential for pharmaceutical R&D, biotechnology, and diagnostic companies developing next-generation antisense oligonucleotides, siRNA, and aptamers.

Application

• Solid-Phase Oligonucleotide Synthesis: As a key phosphoramidite monomer for the automated, stepwise assembly of DNA/RNA strands.
• Therapeutic Oligonucleotide Manufacturing: Production of active pharmaceutical ingredients (APIs) for antisense, siRNA, and miRNA-based drugs.
• Research Probe Development: Synthesis of labeled or modified oligonucleotide probes for genomics, diagnostics, and basic research.
• Aptamer Synthesis: Creation of structured nucleic acid ligands for target binding in diagnostic and therapeutic platforms.
• Process Development & Scale-Up: Serves as a critical raw material for process optimization and cGMP manufacturing of oligonucleotide therapeutics.

Basic Information

Item	Detail
Product Name	[(2S,6R)-6-{N2-Isobutyryl-Guanin-9-Yl}-4-Tritylmorpholin-2-Yl]Methyl Dimethylphosphoramidate Chloridate
CAS No.	956139-25-6
Molecular Formula	C41H46ClN7O5P
Molecular Weight	782.27 g/mol
Synonyms	Guanine Phosphoramidite (N2-Ibu, 4-Trt-morpholino); 5'-O-Dimethoxytrityl-N2-isobutyryl-2'-O-(4-monomethoxytritylaminomorpholinocarbonyl)guanosine-3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite (related structural analog); N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(4-monomethoxytritylaminomorpholinocarbonyl)guanosine-3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite; Morpholino-modified Guanosine Phosphoramidite; Trt-Morpholino G(Ibu) Phosphoramidite; Oligonucleotide Synthesis Building Block 956139-25-6; PMO Precursor Monomer (Guanine).
EINECS	Contact for details

Quality Control

Our [(2S,6R)-6-{N2-Isobutyryl-Guanin-9-Yl}-4-Tritylmorpholin-2-Yl]Methyl Dimethylphosphoramidate Chloridate is manufactured under strict quality systems to ensure batch-to-batch consistency for sensitive oligonucleotide synthesis. Each lot undergoes rigorous analytical testing, including HPLC for purity and 31P/1H NMR for structural confirmation. Certificates of Analysis (COA) detailing all specifications are provided to support your GMP or research-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C ± 5°C under an inert atmosphere (argon or nitrogen) due to its moisture-sensitive and light-sensitive nature. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.