Description

N2-Isobutyryl-n-Trityl-Morpholino Guanosine is a sophisticated, high-purity nucleoside phosphoramidite derivative, a critical building block in the synthesis of oligonucleotides. This compound matters for its role in enabling the precise and efficient construction of modified RNA sequences, which are essential for advanced research and therapeutic development. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic laboratories focused on antisense technology, siRNA development, and other cutting-edge nucleic acid applications.

Application

• Solid-Phase Oligonucleotide Synthesis: As a key phosphoramidite monomer for the automated synthesis of morpholino-modified oligonucleotides.
• Antisense Therapeutic Development: For creating research-grade and pre-clinical antisense oligonucleotides (ASOs) with enhanced nuclease resistance and binding affinity.
• siRNA and RNAi Research: Used in the synthesis of modified guide strands to improve stability and specificity in RNA interference applications.
• Diagnostic Probe Synthesis: Manufacturing of high-specificity nucleic acid probes for diagnostic assays and genomic research.
• Academic & Pharmaceutical R&D: A vital reagent for exploring novel oligonucleotide structures and their biological functions in drug discovery pipelines.
• GMP-Grade Manufacturing: Serves as a starting material for the production of therapeutic oligonucleotides under current Good Manufacturing Practice (cGMP) guidelines.

Basic Information

Product Name	N2-Isobutyryl-n-Trityl-Morpholino Guanosine
CAS No.	956139-24-5
Molecular Formula	C43H48N6O6
Molecular Weight	744.89 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-N2-isobutyryl-2'-O-(morpholinomethyl)guanosine; Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(morpholinomethyl)-N-(2-methyl-1-oxopropyl)-; N2-Ibu-N-Trt-Morpholino-Guanosine; N2-Isobutyryl-5'-O-DMT-2'-O-(morpholinomethyl)guanosine; Trt-Mor-G(Ibu) Phosphoramidite precursor; MMTr-G(Ibu) Monomer; 2'-Morpholino Modified Guanosine Derivative
EINECS	Contact for details

Quality Control

Every batch of N2-Isobutyryl-n-Trityl-Morpholino Guanosine is manufactured and tested to meet stringent quality standards suitable for critical research and development. Our rigorous quality testing ensures high purity and consistency, with comprehensive analysis via HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support development under quality frameworks including ISO 9001 and can supply material aligned with cGMP requirements for advanced therapeutic applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a desiccated environment. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to air, moisture, or ambient light will compromise stability and performance. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.