Description

N2-Isobutyryl-7'-Oh-Morpholino Guanosine is a chemically modified nucleoside derivative, specifically designed as a key building block for advanced oligonucleotide synthesis. This compound is critical for researchers and manufacturers developing next-generation therapeutic and diagnostic agents, particularly in the fields of antisense and RNA-targeting technologies. Its primary value lies in enabling the precise construction of morpholino oligomers with enhanced nuclease resistance and binding affinity. This high-purity intermediate is essential for pharmaceutical R&D, biotechnology companies, and diagnostic kit manufacturers focused on genetic medicine and molecular biology applications.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of Morpholino antisense oligonucleotides (PMOs) for therapeutic applications.
• Genetic Research: Used in the development of gene expression inhibitors and splice-switching oligonucleotides for functional genomics studies.
• Diagnostic Probe Synthesis: Serves as a modified base for creating highly specific and stable nucleic acid probes used in diagnostic assays.
• Bioconjugation: Acts as a starting material for the preparation of labeled nucleosides for tracking and imaging studies.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the pharmacokinetic properties of oligonucleotide drugs.

Basic Information

Product Name	N2-Isobutyryl-7'-Oh-Morpholino Guanosine
CAS No.	956139-23-4
Molecular Formula	C₁₈H₂₆N₆O₇
Molecular Weight	438.44 g/mol
Synonyms	7'-Hydroxy-N2-isobutyrylmorpholino-guanosine; N2-Isobutyryl-7'-hydroxymorpholino-guanosine; Guanosine, N2-(2-methyl-1-oxopropyl)-7'-hydroxymorpholino-; PMO Guanosine Monomer (Isobutyryl protected); Morpholino guanosine derivative; Antisense oligonucleotide building block; Isobutyryl-protected morpholino nucleoside
EINECS	Contact for details

Quality Control

Every batch of N2-Isobutyryl-7'-Oh-Morpholino Guanosine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity, suitable for sensitive pharmaceutical synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.