Description

Defluoro Flumazenil Isothiocyanate is a high-purity, specialized chemical derivative designed for advanced research and development applications. This compound serves as a critical building block and analytical probe in pharmaceutical discovery, particularly for studying benzodiazepine receptor systems. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in developing novel therapeutics or diagnostic agents. Its precise structure enables targeted modifications and labeling studies essential for modern drug development pipelines.

Application

• Pharmaceutical Research & Development: As a key intermediate in the synthesis of novel benzodiazepine receptor ligands and potential therapeutic agents.
• Bioconjugation & Probe Synthesis: The isothiocyanate functional group allows for covalent attachment to proteins, peptides, or other biomolecules, creating labeled probes for receptor binding assays.
• Metabolite & Impurity Reference Standard: Used as an analytical standard in HPLC, LC-MS, or NMR for the identification and quantification of related compounds in complex matrices.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore the pharmacological impact of specific molecular modifications.
• Diagnostic Agent Development: Potential use in the development of targeted imaging agents or diagnostic tools for neurological research.
• Chemical Biology: Serves as a tool compound for investigating protein-ligand interactions and signal transduction pathways involving GABAA receptors.

Basic Information

Product Name	Defluoro Flumazenil Isothiocyanate
CAS No.	954107-48-3
Molecular Formula	C16H10N4O2S2
Molecular Weight	354.40 g/mol
Synonyms	Flumazenil Isothiocyanate, Defluoro Analog; 8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid phenyl ester isothiocyanate derivative; Ro 15-4513 Isothiocyanate analog; Ethyl 8-azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate related compound; GABAA receptor antagonist derivative; Benzodiazepine receptor probe; BZR ligand isothiocyanate
EINECS	Contact for details

Quality Control

Our Defluoro Flumazenil Isothiocyanate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.