Description

Trityl Isothiocyanate is a specialized organic reagent featuring a sterically hindered trityl group attached to a reactive isothiocyanate moiety. This compound is valued for its role as a versatile protecting group and derivatization agent in sophisticated organic synthesis and peptide chemistry. It is primarily utilized by research scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for the development of novel compounds and active ingredients.

Application

• Peptide Synthesis: Used as a protecting group for amino acids, particularly for the selective protection of cysteine and other thiol-containing residues during solid-phase and solution-phase peptide synthesis.
• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex drug candidates, especially those requiring selective modification of amine or thiol functionalities.
• Bioconjugation: Employed for labeling and cross-linking biomolecules such as proteins and antibodies, facilitating the creation of diagnostic probes and targeted drug conjugates.
• Agrochemical Research: Acts as an intermediate in the development of novel pesticides and herbicides, leveraging its reactivity to create new active molecules.
• Material Science: Utilized in the surface functionalization of polymers and nanoparticles to introduce specific chemical handles for further modification.
• Chemical Biology Probes: Applied in the design of activity-based probes for studying enzyme function and mechanism, particularly for cysteine proteases.

Basic Information

Product Name	Trityl Isothiocyanate
CAS No.	1726-94-9
Molecular Formula	C20H15NS
Molecular Weight	301.41 g/mol
Synonyms	Triphenylmethyl isothiocyanate; Trityl thiocyanate isomeric form; NSC 403697; (Isothiocyanatomethyl)triphenylmethane; Triphenylmethane, isothiocyanato-; Triphenylmethyl mustard oil; Trityl-NCS
EINECS	217-034-9

Quality Control

Our Trityl Isothiocyanate is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research and development applications. Each lot is analyzed using advanced techniques including HPLC, NMR, and FTIR to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	142 - 147 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.