Description

4-Methyl-2-Pyrid-4-Yl-1,3-Thiazole-5-Carbonyl Chloride Hydrochloride is a high-purity, advanced pharmaceutical intermediate and versatile organic building block. This compound is critical for research and development in medicinal chemistry, particularly for the synthesis of novel drug candidates targeting a range of therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories, agrochemical manufacturers, and specialty chemical companies engaged in the development of complex heterocyclic molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing thiazole and pyridine pharmacophores.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies for developing new therapeutic agents.
• Agrochemical Synthesis: Intermediate in the production of advanced crop protection agents and pesticides.
• Chemical Biology Probes: Serves as a precursor for creating labeled compounds or probes used in biochemical and cellular assays.
• Material Science Research: Potential monomer or precursor for synthesizing specialized polymers and functional materials.
• Contract Research & Manufacturing (CRAM): Supplied to organizations offering custom synthesis and process development services.

Basic Information

Product Name	4-Methyl-2-Pyrid-4-Yl-1,3-Thiazole-5-Carbonyl Chloride Hydrochloride
CAS No.	953408-88-3
Molecular Formula	C11H8ClN2OS • HCl
Molecular Weight	289.12 g/mol (Free base: 252.71 g/mol)
Synonyms	4-Methyl-2-(pyridin-4-yl)-1,3-thiazole-5-carbonyl chloride hydrochloride; 2-(4-Pyridinyl)-4-methyl-5-thiazolecarbonyl chloride hydrochloride; 4-Methyl-2-(4-pyridinyl)-1,3-thiazole-5-carbonyl chloride HCl; 5-Carbonyl chloride, 4-methyl-2-(4-pyridinyl)-1,3-thiazole, hydrochloride; Thiazole-5-carbonyl chloride derivative
EINECS	Contact for details

Quality Control

Our 4-Methyl-2-Pyrid-4-Yl-1,3-Thiazole-5-Carbonyl Chloride Hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.