Description

5-Isothiocyanato-3-(Trifluoromethyl)Picolinonitrile is a high-value, multifunctional heterocyclic building block containing both isothiocyanate and nitrile functional groups. This compound is critical for the synthesis of novel agrochemicals and pharmaceuticals, where it serves as a key intermediate for introducing the trifluoromethylpyridine moiety, a structural feature known to enhance biological activity and metabolic stability. It is primarily utilized by research and development chemists in the agrochemical and pharmaceutical industries for creating new active ingredients and advanced materials.

Application

• Agrochemical Intermediate: A key precursor in the synthesis of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing trifluoromethylpyridine scaffold.
• Pharmaceutical Building Block: Used in medicinal chemistry for the development of active pharmaceutical ingredients (APIs), particularly in creating molecules with improved potency and pharmacokinetic profiles.
• Ligand Synthesis: Serves as a versatile starting material for constructing complex ligands used in catalysis and material science applications.
• Chemical Biology Probe Development: The reactive isothiocyanate group allows for selective conjugation with biomolecules, making it useful for creating probes and labeled compounds.
• Advanced Material Research: Employed in the research and development of specialty polymers and functional materials with unique electronic or surface properties.

Basic Information

Product Name	5-Isothiocyanato-3-(Trifluoromethyl)Picolinonitrile
CAS No.	951753-87-0
Molecular Formula	C8H2F3N3S
Molecular Weight	229.18 g/mol
Synonyms	3-(Trifluoromethyl)-5-isothiocyanatopicolinonitrile; 2-Cyano-5-isothiocyanato-3-(trifluoromethyl)pyridine; 5-Isothiocyanato-3-trifluoromethylpyridine-2-carbonitrile; 2-Pyridinecarbonitrile, 5-isothiocyanato-3-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 5-Isothiocyanato-3-(Trifluoromethyl)Picolinonitrile is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and scale-up applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality management system is designed to meet the stringent requirements of our global B2B partners in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.