Description

o-(2-Aminoethyl)-O'-(2-Azidoethyl)Triethylene Glycol is a heterobifunctional polyethylene glycol (PEG) derivative engineered for advanced bioconjugation and materials science applications. This compound matters because it provides a versatile, water-soluble linker with orthogonal reactive groups—a primary amine and an azide—enabling sequential, site-specific coupling via amine-reactive chemistries and copper-free click reactions. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostics industries for creating stable PEGylated therapeutics, functionalized nanoparticles, hydrogel networks, and sophisticated diagnostic probes.

Application

• Bioconjugation and PEGylation: Site-specific modification of proteins, peptides, and antibodies to improve solubility, stability, and pharmacokinetics.
• Click Chemistry Scaffold: As a key building block for copper-free (strain-promoted) azide-alkyne cycloaddition (SPAAC) to create complex biomolecular assemblies.
• Functionalized Nanoparticles: Surface modification of liposomes, quantum dots, and polymeric nanoparticles for targeted drug delivery and imaging.
• Hydrogel Formation: Cross-linking agent for creating biocompatible, tunable hydrogels used in tissue engineering and 3D cell culture.
• Diagnostic Probe Synthesis: Linker for attaching fluorophores, quenchers, or other reporter molecules to biomolecules in assay development.
• Surface Immobilization: Functionalization of gold surfaces, glass slides, or chips for biosensor and microarray fabrication.
• Polymer Chemistry: Monomer or macromonomer for synthesizing functional, stimuli-responsive copolymers.
• Antibody-Drug Conjugate (ADC) Linker: Potential use in constructing next-generation ADCs with controlled drug-to-antibody ratios.

Basic Information

Product Name	o-(2-Aminoethyl)-O'-(2-Azidoethyl)Triethylene Glycol
CAS No.	951671-92-4
Molecular Formula	C12H25N5O4
Molecular Weight	303.36 g/mol
Synonyms	2,2'-(Ethane-1,2-diylbis(oxy))bis(ethan-1-amine), N-(2-Azidoethyl) derivative; Amino-PEG3-Azide; Azido-PEG3-Amine; 8-Aza-3,6,12,15-tetraoxa-9-azidopentadecan-1-amine; Heterobifunctional PEG3 linker, Amine-Azide; 1-Amino-11-azido-3,6,9-trioxaundecane; N3-PEG3-NH2; Amine-PEG3-N3
EINECS	Contact for details

Quality Control

Our o-(2-Aminoethyl)-O'-(2-Azidoethyl)Triethylene Glycol is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for sensitive research and development applications. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and FT-IR for structural confirmation and purity assessment. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and functional group integrity is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product in a freezer at -20°C or below under desiccant. The material is moisture-sensitive and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation. Store away from strong oxidizing agents and acids.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Amine Content (Titration)	≥ 90% of theoretical
Azide Content (NMR)	≥ 90% of theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.