Description

Dnp-Peg3-Azide (CAS NO 951671-87-7) is a specialized bifunctional linker molecule featuring a dinitrophenyl (DNP) quenching group, a triethylene glycol (PEG3) spacer, and a terminal azide functional group. This unique structure is engineered for advanced bioconjugation and click chemistry applications, enabling precise labeling and cross-linking of biomolecules. It is an essential research-grade reagent for scientists in pharmaceutical R&D, proteomics, and materials science who require reliable, high-purity building blocks for developing novel diagnostics and therapeutics.

Application

• Bioconjugation and Protein Labeling: Utilized for site-specific modification of proteins and antibodies via its reactive azide group, often in conjunction with alkyne-functionalized probes through copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Proteomics and Biomolecular Research: Serves as a key reagent for synthesizing activity-based probes (ABPs) or affinity tags to study enzyme function, protein-protein interactions, and cellular pathways.
• Development of ADC Linkers: Acts as a model compound or intermediate in the design and synthesis of cleavable linkers for Antibody-Drug Conjugates (ADCs), leveraging the PEG spacer for improved solubility and pharmacokinetics.
• Materials Science and Surface Functionalization: Used to introduce azide functionalities onto polymers, nanoparticles, or solid surfaces for subsequent "click" modification to create advanced biomaterials.
• Fluorescence Quenching Studies: The DNP group acts as an efficient quencher in Förster Resonance Energy Transfer (FRET)-based assays and molecular beacons.
• Chemical Biology Tool Development: A critical building block for creating cross-linkers, affinity purification handles, and other specialized reagents for chemical biology applications.

Basic Information

Product Name	Dnp-Peg3-Azide
CAS No.	951671-87-7
Molecular Formula	C19H28N6O8
Molecular Weight	468.46 g/mol
Synonyms	2,4-Dinitrophenyl-PEG3-azide; DNP-PEG3-N3; 1-Azido-2,5,8,11-tetraoxatridecan-13-yl 2,4-dinitrobenzene; 13-(2,4-Dinitrophenyl)-2,5,8,11-tetraoxatridecan-1-azide; Azido-PEG3-DNP; DNP-PEG(3)-N3; PEG3-DNP-Azide; N3-PEG3-DNP
EINECS	Contact for details

Quality Control

Our Dnp-Peg3-Azide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. The compound is light-sensitive (store away from light) and should be allowed to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange viscous oil or solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.