Description

n-[5-(1,1-Dimethylethyl)-3-Isoxazolyl]-N'-[4-[7-[2-(4-Morpholinyl)Ethoxy]Imidazo[2,1-B]Benzothiazol-2-Yl]Phenyl]Urea Hydrochloride is a high-purity, non-peptidic small molecule compound designed for advanced research and development. This compound is of significant interest for its potential as a selective kinase inhibitor, making it a valuable tool for investigating cellular signaling pathways. It is primarily utilized by pharmaceutical R&D teams and academic researchers focused on oncology, immunology, and metabolic disease studies.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or active pharmaceutical ingredient (API) in the discovery of novel kinase-targeted therapeutics.
• Biochemical Assay Development: Used as a reference standard or probe compound in high-throughput screening (HTS) and enzyme inhibition assays.
• Mechanism of Action (MoA) Studies: Employed to elucidate specific kinase pathways involved in disease pathology and validate drug targets.
• Preclinical Studies: Utilized in in vitro and in vivo models to assess efficacy, pharmacokinetics, and toxicity profiles of potential drug candidates.
• Chemical Biology: Acts as a molecular tool for studying protein function and signal transduction networks within cells.
• Process Chemistry: Used as a starting material or intermediate for the synthesis of more complex, targeted molecular entities.

Basic Information

Product Name	n-[5-(1,1-Dimethylethyl)-3-Isoxazolyl]-N'-[4-[7-[2-(4-Morpholinyl)Ethoxy]Imidazo[2,1-B]Benzothiazol-2-Yl]Phenyl]Urea Hydrochloride
CAS No.	950769-62-7
Molecular Formula	C29H33N7O4S · HCl
Molecular Weight	612.14 g/mol (Free base: 575.68 g/mol)
Synonyms	N-[5-(tert-Butyl)-3-isoxazolyl]-N'-[4-[7-[2-(4-morpholinyl)ethoxy]imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl]urea hydrochloride; UNII-2Q8K5Q8E4I; 2Q8K5Q8E4I; BIRB 796 hydrochloride; Doramapimod hydrochloride; p38 MAP kinase inhibitor BIRB 796 HCl
EINECS	Contact for details

Quality Control

Our production of n-[5-(1,1-Dimethylethyl)-3-Isoxazolyl]-N'-[4-[7-[2-(4-Morpholinyl)Ethoxy]Imidazo[2,1-B]Benzothiazol-2-Yl]Phenyl]Urea Hydrochloride adheres to stringent quality protocols suitable for research and development applications. Each batch is characterized and tested to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing comprehensive analytical results from techniques including HPLC, NMR, and MS are provided to guarantee traceability and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Keep container tightly sealed in a cool, dry, and well-ventilated place. For long-term storage, consider desiccant use and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.