Description

Quizartinib is a potent and highly selective small-molecule inhibitor of FMS-like tyrosine kinase 3 (FLT3), specifically targeting the FLT3-ITD mutation. This compound matters as a critical research tool and active pharmaceutical ingredient (API) for developing targeted therapies in oncology. It is primarily needed by pharmaceutical R&D teams, academic researchers, and contract manufacturing organizations (CMOs) focused on acute myeloid leukemia (AML) and other hematologic malignancies.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) in the development of novel FLT3-targeted cancer therapeutics.
• Preclinical & Clinical Studies: Used in in vitro and in vivo studies to investigate the efficacy, pharmacokinetics, and mechanism of action of FLT3 inhibition.
• Biochemical Assay Development: Employed as a selective inhibitor to validate assays and screen for FLT3 kinase activity in high-throughput settings.
• Oncology Target Validation: A crucial tool for understanding the role of FLT3-ITD mutations in cancer progression and resistance mechanisms.
• Contract Manufacturing: Supplied as a high-purity intermediate or API for cGMP manufacturing of clinical trial materials and commercial drug products.

Basic Information

Product Name	Quizartinib
CAS No.	950769-58-1
Molecular Formula	C₂₉H₃₂ClFN₄O₃
Molecular Weight	530.04 g/mol
Synonyms	AC220; Quizartinib dihydrochloride (salt form); 6-(5-tert-Butyl-isoxazol-3-ylamino)-7-fluoro-3-methyl-2-[(E)-2-(1-methyl-piperidin-4-yl)-vinyl]-3H-quinazolin-4-one; UNII-5K5C6W5J8I; FLT3 Inhibitor AC220; 4(3H)-Quinazolinone, 6-[[(5-tert-butyl-3-isoxazolyl)amino]-7-fluoro-3-methyl-2-[(1E)-2-(1-methyl-4-piperidinyl)ethenyl]-
EINECS	Contact for details

Quality Control

Our Quizartinib is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and comprehensive impurity profiling. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research and cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity	≤0.5%
Total Impurities	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.