Description

Tie2 Kinase Inhibitor CAS NO 948557-43-5 is a potent and selective small molecule inhibitor targeting the Tie2 (TEK) receptor tyrosine kinase. This compound is a critical research tool for investigating angiogenesis and tumor vascularization pathways, offering significant value in preclinical drug discovery. It is primarily needed by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on developing novel oncology therapeutics and studying vascular biology.

Application

• Angiogenesis Research: Fundamental tool for studying the role of the Tie2 signaling pathway in blood vessel formation and maturation.
• Oncology Drug Discovery: Used in high-throughput screening and lead optimization for developing anti-cancer therapies that target tumor vasculature.
• Cell-Based Assays: Employed to inhibit Tie2 kinase activity in cellular models to elucidate downstream signaling effects and validate drug targets.
• Preclinical Studies: Utilized in animal models to evaluate the efficacy of anti-angiogenic strategies for cancer and other angiogenesis-dependent diseases.
• Biochemical Profiling: Serves as a reference standard in kinase selectivity panels to assess the specificity of new inhibitor compounds.
• Vascular Biology Studies: Applied in research exploring lymphatic development, vascular stability, and related pathological conditions.

Basic Information

Item	Details
Product Name	Tie2 Kinase Inhibitor
CAS No.	948557-43-5
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	N-[5-[[(2S)-2-[[(3R)-3-[(1H-Indazol-5-ylamino)-2-oxo-1-pyrrolidinyl]methyl]-1-piperidinyl]carbonyl]-2-pyridinyl]methyl]-N-methylglycine; Tie-2 Kinase Inhibitor; CAS 948557-43-5; Tie2 Inhibitor; TEK Inhibitor; Angiopoietin-1 Receptor Inhibitor; Research Compound 948557-43-5
EINECS	Contact for details

Quality Control

Our Tie2 Kinase Inhibitor is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and NMR for structural confirmation, to ensure high chemical integrity and batch-to-batch consistency suitable for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.