Description

4-(Bromomethyl)-3-(Trifluoromethyl)-Benzoylchloride is a highly reactive and versatile aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both a reactive benzoyl chloride group and a bromomethyl substituent adjacent to a trifluoromethyl group, makes it an invaluable precursor for constructing complex molecules with tailored properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing advanced functional molecules used in electronic displays and organic light-emitting diodes (OLEDs).
• Polymer Modification Agent: Employed to introduce functional side chains into polymer backbones, altering physical properties like solubility, thermal stability, and refractive index.
• Cross-Coupling Reactions: The bromomethyl group facilitates Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Peptidomimetics & PROTACs: Utilized in medicinal chemistry for constructing peptide mimics and Proteolysis-Targeting Chimeras (PROTACs) for targeted protein degradation.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D labs for exploring new synthetic methodologies and creating novel chemical entities.

Basic Information

Item	Details
Product Name	4-(Bromomethyl)-3-(Trifluoromethyl)-Benzoylchloride
CAS No.	948553-14-8
Molecular Formula	C9H5BrClF3O
Molecular Weight	301.49 g/mol
Synonyms	3-(Trifluoromethyl)-4-(bromomethyl)benzoyl chloride; 4-(Bromomethyl)-α,α,α-trifluoro-m-toluoyl chloride; 4-Bromomethyl-3-trifluoromethylbenzoyl chloride; m-Toluoyl chloride, 4-(bromomethyl)-α,α,α-trifluoro-; Benzoyl chloride, 4-(bromomethyl)-3-(trifluoromethyl)-; [4-(Bromomethyl)-3-(trifluoromethyl)phenyl]methanone chloride
EINECS	Contact for details

Quality Control

Our production of 4-(Bromomethyl)-3-(Trifluoromethyl)-Benzoylchloride adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment, NMR for structural confirmation, and Karl Fischer titration for moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your internal specifications and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent hydrolysis. Keep away from strong bases, oxidizers, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.