Description

2-Fluoro-3-(Trifluoromethoxy)-Benzoylchloride is a high-purity, multi-functional aromatic acid chloride intermediate essential for advanced organic synthesis. Its core value lies in enabling the precise introduction of the 2-fluoro-3-(trifluoromethoxy)benzoyl moiety, a key structural motif that imparts desirable properties like metabolic stability and lipophilicity to target molecules. This compound is critically needed by R&D and production teams in the pharmaceutical and agrochemical industries for developing new active ingredients, particularly in the synthesis of complex heterocycles and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in central nervous system (CNS) and antiviral research.
• Agrochemical Synthesis: Used in the production of advanced herbicides and insecticides, where the fluorine and trifluoromethoxy groups enhance biological activity and environmental stability.
• Liquid Crystal Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic displays.
• Polymer Modification: Employed to introduce functional side chains into polymers, altering their chemical resistance and surface properties.
• Peptide Coupling Reagent: Acts as a coupling agent in peptide synthesis to form amide bonds under mild conditions.
• Custom Synthesis & Contract Manufacturing: A vital reagent for fine chemical and custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	2-Fluoro-3-(Trifluoromethoxy)-Benzoylchloride
CAS No.	948294-35-7
Molecular Formula	C8H3ClF4O2
Molecular Weight	242.56 g/mol
Synonyms	2-Fluoro-3-(trifluoromethoxy)benzoyl chloride; 3-(Trifluoromethoxy)-2-fluorobenzoic acid chloride; 2-Fluoro-α,α,α-trifluoro-m-anisoyl chloride; Benzoyl chloride, 2-fluoro-3-(trifluoromethoxy)-; 948294-35-7; 2-Fluoro-3-trifluoromethoxybenzoyl chloride
EINECS	Contact for details

Quality Control

Our 2-Fluoro-3-(Trifluoromethoxy)-Benzoylchloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.