Description

Allisartan Isoproxil CAS NO 947331-05-7 is a non-peptide angiotensin II receptor blocker (ARB) used as an antihypertensive active pharmaceutical ingredient (API). This compound matters for its role in the development of effective and well-tolerated medications for managing high blood pressure. Pharmaceutical manufacturers and research organizations in the global life sciences sector require this high-purity intermediate for the synthesis of finished dosage forms.

Application

• Pharmaceutical API Synthesis: Primary use as the active ingredient in antihypertensive tablet formulations.
• Cardiovascular Drug Development: Key intermediate in R&D for new angiotensin II receptor antagonist medications.
• Generic Drug Manufacturing: Sourcing for the production of generic versions of established hypertension treatments.
• Clinical Research Materials: Supply of characterized material for pharmacokinetic and pharmacodynamic studies.
• Reference Standard Production: Sourcing of high-purity material for analytical testing and quality control laboratories.
• Combination Therapy Components: Use in fixed-dose combination drugs alongside other antihypertensive agents like diuretics.

Basic Information

Product Name	Allisartan Isoproxil
CAS No.	947331-05-7
Molecular Formula	C₂₄H₂₆N₆O₃
Molecular Weight	446.51 g/mol
Synonyms	Allisartan Isoproxil; Allisartan Isoproxilum; 2-Butyl-5-({4-[2-(1H-tetrazol-5-yl)phenyl]phenyl}methyl)-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acid isopropyl ester; S-(-)-1-{[2'-(1H-Tetrazol-5-yl)biphenyl-4-yl]methyl}-2-butyl-4-chloro-1H-imidazole-5-carboxylic Acid 1-{[2'-(1H-Tetrazol-5-yl)biphenyl-4-yl]methyl}-2-butyl-4-chloroimidazol-5-carboxylate; Allisartan Isoproxil API
EINECS	Contact for details

Quality Control

Our Allisartan Isoproxil is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity pharmaceutical grade specifications, typically exceeding 98.5% purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing results for identity, assay, related substances, residual solvents, and heavy metals. Our quality commitment aligns with ICH guidelines and supports regulatory filings for drug master files (DMFs).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 1.0%; Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.