Description

Guanfacine CAS NO 29110-47-2 is a selective α-2A adrenergic receptor agonist, recognized for its high pharmacological activity. This compound is a critical active pharmaceutical ingredient (API) essential for the formulation of central nervous system medications. It is primarily required by pharmaceutical manufacturers and research institutions developing treatments for hypertension and attention deficit hyperactivity disorder (ADHD).

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications for managing hypertension.
• Neuropharmacology: Key component in extended-release formulations for the treatment of ADHD in children and adults.
• Clinical Research: Used as a reference standard in pharmacokinetic and pharmacodynamic studies.
• Drug Development: Serves as a crucial intermediate in the synthesis of novel CNS-targeting therapeutic agents.
• Generic Drug Manufacturing: Essential for producing cost-effective generic versions of branded guanfacine medications.
• Biochemical Research: Utilized in vitro studies to investigate α-2 adrenergic receptor signaling pathways.

Basic Information

Product Name	Guanfacine
CAS No.	29110-47-2
Molecular Formula	C9H9Cl2N3O
Molecular Weight	246.09 g/mol
Synonyms	Guanfacine Hydrochloride (common salt form); Estulic; Tenex; Intuniv; N-Amidino-2-(2,6-dichlorophenyl)acetamide; 2-[(Dichlorophenyl)acetyl]guanidine; 1-(2,6-Dichlorophenyl)acetyl]guanidine; BR-750
EINECS	249-449-8

Quality Control

Our Guanfacine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity: ≤ 0.5%; Total impurities: ≤ 1.5%
Microbial Limits	Meets Ph. Eur. 2.6.12/2.6.13 requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.