Description

Losartan Potassium is a potent and selective angiotensin II receptor antagonist (ARB) used primarily as an active pharmaceutical ingredient (API). This compound is critical for the formulation of antihypertensive medications that help manage high blood pressure and protect against kidney damage in patients with type 2 diabetes. It is essential for pharmaceutical manufacturers, research institutions, and compounding facilities focused on cardiovascular and metabolic health therapeutics.

Application

• Pharmaceutical API: Primary use as the active ingredient in finished dosage forms for the treatment of hypertension (high blood pressure).
• Cardiovascular Drug Formulations: Used in tablets, often in combination with other APIs like hydrochlorothiazide, for enhanced therapeutic effect.
• Renal Protection Therapy: Key component in medications prescribed for diabetic nephropathy to slow the progression of kidney disease.
• Generic Drug Manufacturing: Serves as the core API for producing cost-effective generic versions of branded antihypertensive drugs.
• Clinical Research: Utilized in preclinical and clinical studies for developing new cardiovascular treatment protocols and combination therapies.
• Reference Standard: High-purity grades are used as analytical reference standards in quality control laboratories for method development and validation.

Basic Information

Product Name	Losartan Potassium
CAS No.	124750-99-8
Molecular Formula	C22H22ClKN6O
Molecular Weight	461.01 g/mol
Synonyms	Losartan K; 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol monopotassium salt; Dup 753; MK-954; Cozaar (Brand Name); (2-Butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol potassium salt
EINECS	Contact for details

Quality Control

Our Losartan Potassium is manufactured under strict quality management systems, targeting compliance with major pharmacopoeial standards such as USP and EP. Each batch undergoes comprehensive analytical testing including identification, assay, impurity profiling, and residual solvent analysis. A Certificate of Analysis (COA) documenting all test results is provided with every shipment to ensure full traceability and regulatory compliance for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation and ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	NMT 2.0%
Related Substances (HPLC)	Total impurities: NMT 1.0% Any individual impurity: NMT 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	NMT 20 ppm
Sulfated Ash	NMT 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.