Description

Ketanserin is a highly selective serotonin 5-HT2A receptor antagonist with significant pharmacological research applications. This compound is a critical tool for investigating cardiovascular function, platelet aggregation, and central nervous system pathways. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and contract research organizations (CROs) for preclinical studies and biochemical assay development.

Application

• Pharmacological Research: A key reference standard and active agent in studies targeting serotonin (5-HT2A) receptor mechanisms.
• Cardiovascular Studies: Used to investigate the role of serotonin in hypertension, vasoconstriction, and vascular smooth muscle tone.
• Neuropharmacology: Essential for exploring serotonin's influence on mood, perception, and central nervous system disorders.
• Platelet Function Research: Employed to study the inhibition of serotonin-mediated platelet aggregation and thrombus formation.
• Biochemical Assay Development: Serves as a precise control and calibration standard in receptor binding assays and high-throughput screening (HTS).
• Reference Standard: Used in analytical method development and validation for quality control in pharmaceutical manufacturing.

Basic Information

Product Name	Ketanserin
CAS No.	74050-98-9
Molecular Formula	C22H22FN3O3
Molecular Weight	395.43 g/mol
Synonyms	3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,4(1H,3H)-quinazolinedione; R 41 468; R-41468; Ketensin; Sufrexal; 5-HT2A Receptor Antagonist
EINECS	Contact for details

Quality Control

Our Ketanserin is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support compliance with relevant standards for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.