Description

Debrisoquine is a selective and potent inhibitor of the cytochrome P450 enzyme CYP2D6, making it a critical pharmacological tool for drug metabolism and pharmacogenetics research. Its primary value lies in its ability to phenotype individuals for CYP2D6 activity, which is essential for predicting drug efficacy and toxicity in clinical development. This compound is therefore indispensable for pharmaceutical R&D laboratories, clinical research organizations, and academic institutions focused on pharmacokinetics and personalized medicine.

Application

• CYP2D6 Phenotyping: Used as a probe drug to determine an individual's metabolic status (e.g., poor, intermediate, extensive, or ultra-rapid metabolizer) for the CYP2D6 enzyme.
• Drug-Drug Interaction Studies: Employed in vitro and in vivo to assess the inhibition potential of new chemical entities on CYP2D6, a critical step in preclinical safety assessment.
• Pharmacogenetics Research: Serves as a standard tool to study genetic polymorphisms of CYP2D6 and their impact on drug response and adverse events.
• Metabolic Pathway Elucidation: Helps identify and characterize metabolites formed via the CYP2D6 pathway for new drug candidates.
• Enzyme Kinetics: Used to determine inhibitory constants (Ki) and mechanism of action for CYP2D6 inhibitors.
• Reference Standard: Acts as a high-purity analytical standard for quantification in biological matrices during clinical studies.

Basic Information

Product Name	Debrisoquine
CAS No.	1131-64-2
Molecular Formula	C10H13N3
Molecular Weight	175.23 g/mol
Synonyms	Debrisochin; Debrisoquin; Declinax; Ro 5-3307/1; 3,4-Dihydro-2(1H)-isoquinolinecarboximidamide; 1,2,3,4-Tetrahydroisoquinoline-2-carboximidamide
EINECS	214-469-9

Quality Control

Our Debrisoquine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (IR, NMR), to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.