Description

Isavuconazonium Sulfate is the water-soluble prodrug of the active triazole antifungal agent, isavuconazole. This compound is critically important for the pharmaceutical industry as a key active pharmaceutical ingredient (API) in the treatment of serious invasive fungal infections. It is primarily required by pharmaceutical manufacturers and research institutions for the development and production of antifungal medications. The product is supplied under stringent quality controls to ensure its efficacy and safety in final drug formulations.

Application

• Active Pharmaceutical Ingredient (API): Primary use in the formulation of antifungal injectable and oral dosage forms.
• Antifungal Drug Synthesis: Serves as the crucial precursor in the synthesis of the antifungal drug Isavuconazole.
• Pharmaceutical Research & Development: Used in preclinical and clinical studies for developing new antifungal therapies and combination treatments.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.
• Hospital Compounding: Potential use in specialized hospital pharmacy compounding for tailored patient treatments, where applicable.

Basic Information

Product Name	Isavuconazonium Sulfate
CAS No.	946075-13-4
Molecular Formula	C35H35F2N8O5S
Molecular Weight	717.76 g/mol
Synonyms	Isavuconazonium sulfate; BAL-8557; (2R,3R)-2-(2,5-Difluorophenyl)-3-(4-{[(3R,5R)-5-{[(1-methyl-1H-1,2,4-triazol-5-yl)thio]methyl}-1-(2-oxotetrahydro-2H-pyran-4-yl)pyrrolidin-3-yl]oxy}phenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-yl sulfate; Cresemba (prodrug component); Isavuconazole prodrug sulfate
EINECS	Contact for details

Quality Control

Our Isavuconazonium Sulfate is manufactured and tested to meet the highest standards for pharmaceutical active ingredients. Quality assurance protocols are aligned with current Good Manufacturing Practices (cGMP). Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, ensuring compliance with stringent pharmacopeial requirements for API production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.