Description

R-Afatinib CAS NO 945553-91-3 is a high-purity, enantiomerically pure form of the potent and irreversible tyrosine kinase inhibitor, afatinib. This compound is a critical advanced intermediate and reference standard for pharmaceutical research and development, particularly in the field of targeted cancer therapies. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology industries who require a reliable, high-quality building block for the synthesis of novel therapeutics or for use as a certified analytical standard.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of the active pharmaceutical ingredient (API) Afatinib, used in targeted cancer treatments.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control in API manufacturing.
• Biochemical Research: Used in preclinical studies to investigate the mechanisms of action of EGFR (Epidermal Growth Factor Receptor) and ErbB family kinase inhibition.
• Process Development & Optimization: Employed in R&D laboratories for developing and scaling up efficient synthetic routes for afatinib production.
• Impurity Profiling: Utilized to identify, quantify, and control stereoisomeric impurities during the manufacturing process to ensure final product purity.

Basic Information

Product Name	R-Afatinib
CAS No.	945553-91-3
Molecular Formula	C24H25ClFN5O3
Molecular Weight	485.94 g/mol
Synonyms	(2R)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-oxolan-3-yl]oxy]quinazolin-6-yl]-4-(dimethylamino)but-2-enamide; (R)-Afatinib; Afatinib R-Enantiomer; BIBW 2992 R-Enantiomer; (R)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydrofuran-3-yl]oxy]quinazolin-6-yl]-4-(dimethylamino)but-2-enamide
EINECS	Contact for details

Quality Control

Our R-Afatinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess determination, to ensure it meets the high-purity standards required for pharmaceutical R&D and manufacturing. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and impurities is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.