Description

Decernotinib is a potent and selective Janus kinase 3 (JAK3) inhibitor, representing a significant class of therapeutic agents for targeted immunomodulation. Its primary value lies in its high selectivity for JAK3, which is crucial for cytokine signaling in immune cells, offering a pathway for developing treatments with potentially improved safety profiles. This compound is essential for pharmaceutical R&D teams and contract research organizations (CROs) focused on advancing therapies for autoimmune diseases, inflammatory conditions, and organ transplant rejection.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the discovery and development of novel JAK3-targeted therapeutics.
• Autoimmune Disease Studies: Used in preclinical and clinical research for conditions like rheumatoid arthritis, psoriasis, and inflammatory bowel disease (IBD) due to its mechanism of action.
• Immunology & Cell Signaling Research: A critical tool compound for studying the JAK-STAT signaling pathway, T-cell activation, and lymphocyte function in academic and industrial laboratories.
• Process Chemistry & Scale-Up: Employed in the development and optimization of synthetic routes for the commercial production of JAK3 inhibitor drugs.
• Biochemical Assay Development: Utilized as a high-purity inhibitor to validate and screen for JAK3 activity in enzymatic and cellular assays.

Basic Information

Item	Detail
Product Name	Decernotinib
CAS No.	944842-54-0
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	VX-509; (3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-3-carboxamide; (3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-3-pyrrolidinecarboxamide; VX 509; JAK3 Inhibitor VX-509
EINECS	Contact for details

Quality Control

Our Decernotinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, which includes results from HPLC, NMR, and MS analyses. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	<20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.