Description

Mocetinostat Hydrobromide CAS NO 944537-89-7 is a potent and selective small molecule inhibitor of histone deacetylase (HDAC) enzymes, specifically targeting Class I HDACs. This compound is a critical research tool and pharmaceutical intermediate for developing novel epigenetic therapies. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and contract manufacturing organizations (CMOs) focused on oncology and other disease areas where HDAC modulation is a therapeutic target.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) in preclinical and clinical studies for cancer therapeutics.
• Oncology Drug Discovery: Used as a potent HDAC inhibitor to study epigenetic mechanisms, cell cycle arrest, and apoptosis in various cancer cell lines.
• Biochemical Assay Development: Employed as a critical component in high-throughput screening (HTS) assays to identify and validate new HDAC-targeting compounds.
• Academic & Institutional Research: Facilitates fundamental research in epigenetics, gene expression regulation, and signal transduction pathways.
• Combination Therapy Studies: Investigated in conjunction with other chemotherapeutic agents to evaluate synergistic effects and overcome drug resistance.
• Process Chemistry & Scale-Up: Acts as an intermediate for process optimization and the GMP-compliant synthesis of finished drug products.

Basic Information

Product Name	Mocetinostat Hydrobromide
CAS No.	944537-89-7
Molecular Formula	C₂₂H₂₀N₄O₃ • HBr
Molecular Weight	469.33 g/mol (for the hydrobromide salt)
Synonyms	MGCD0103 Hydrobromide; MGCD-0103 HBr; N-(2-Aminophenyl)-4-[[(4-pyridin-3-ylpyrimidin-2-yl)amino]methyl]benzamide hydrobromide; MGCD 0103; Moce­tinostat HBr; HDAC Inhibitor MGCD0103; Benzamide, N-(2-aminophenyl)-4-[[[4-(3-pyridinyl)-2-pyrimidinyl]amino]methyl]-, hydrobromide (1:1)
EINECS	Contact for details

Quality Control

Our Mocetinostat Hydrobromide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation via spectroscopic methods, and stringent control of residual solvents and impurities. Certificates of Analysis (COA) detailing lot-specific results are provided and can be tailored to meet specific pharmacopeial or client requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.