Description

Bkm120 (Nvp-Bkm120, Buparlisib) is a potent, orally bioavailable, and selective pan-class I phosphatidylinositol 3-kinase (PI3K) inhibitor. This compound is a critical research tool and pharmaceutical intermediate for investigating and developing novel cancer therapeutics targeting the PI3K/AKT/mTOR signaling pathway. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies engaged in oncology drug discovery and preclinical studies.

Application

• Pharmaceutical Research & Development: As a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel oncology drugs.
• Biochemical & Cell-Based Assays: Used as a selective inhibitor to study the role of PI3K signaling in cellular processes such as proliferation, survival, and metabolism.
• Preclinical Studies: Employed in in vitro and in vivo models to evaluate the efficacy and mechanism of action of PI3K inhibition for various cancer types.
• Signal Transduction Pathway Analysis: A vital tool for dissecting the complex PI3K/AKT/mTOR pathway and its crosstalk with other oncogenic pathways.
• High-Throughput Screening (HTS): Serves as a control compound in screening campaigns to identify new PI3K inhibitors or modulators.
• Chemical Biology: Used in probe development to understand protein-ligand interactions and downstream effects of PI3K inhibition.

Basic Information

Product Name	Bkm120 (Nvp-Bkm120, Buparlisib)
CAS No.	944396-07-0
Molecular Formula	C18H21F3N6O2
Molecular Weight	410.40 g/mol
Synonyms	Buparlisib; NVP-BKM120; BKM120; 5-[2,6-Di(4-morpholinyl)-4-pyrimidinyl]-4-(trifluoromethyl)-2-pyridinamine; BKM 120; NVP-BKM-120; BKM-120
EINECS	Contact for details

Quality Control

Our Bkm120 is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research and development purposes. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for pharmaceutical intermediates, and specifications can be aligned with client requirements for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.