Description

Simotinib is a potent and selective small molecule kinase inhibitor with significant research and development value. This compound is primarily utilized as a key pharmaceutical intermediate or active pharmaceutical ingredient (API) in the development of targeted cancer therapies. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical synthesis sectors who require high-purity building blocks for oncology drug discovery and development programs.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel tyrosine kinase inhibitor (TKI) drugs.
• Oncology Research: Used as a reference standard or active compound in preclinical studies targeting specific kinase pathways involved in cancer cell proliferation.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) and enzyme inhibition assays to study kinase function and drug mechanism of action.
• API Synthesis: Acts as the core scaffold or precursor in the multi-step manufacturing process of finished dosage forms for clinical trials.
• Academic Research: Utilized in university and institutional labs for fundamental research into signal transduction and targeted therapy.

Basic Information

Product Name	Simotinib
CAS No.	944258-89-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Simotinib; 944258-89-3; UNII-7VJ280101I; 7VJ280101I; CHEMBL2103875; BDBM50190031; AKOS009158974; (3Z)-3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one (common structural core name - illustrative).
EINECS	Contact for details

Quality Control

Our Simotinib is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for pharmaceutical research and development. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.