Description

Amphotericin B, 13-o-Methyl-, (13S)- is a chemically modified derivative of the potent polyene macrolide antifungal agent, Amphotericin B. This specific stereoisomer is of significant interest in pharmaceutical research for the development of novel antifungal therapies with potentially improved therapeutic profiles. It serves as a critical intermediate and reference standard for researchers and manufacturers in the life sciences sector. The compound is primarily utilized in advanced R&D for studying structure-activity relationships and developing new antifungal agents.

Application

• Pharmaceutical Research & Development: As a key intermediate in the synthesis of novel antifungal drug candidates.
• Reference Standard: For analytical method development, validation, and quality control in pharmaceutical manufacturing.
• Biochemical Studies: To investigate the mechanism of action and resistance pathways of polyene antifungals.
• Structure-Activity Relationship (SAR) Studies: For modifying the amphotericin B scaffold to enhance efficacy and reduce toxicity.
• Academic Research: In university and institutional labs focused on medicinal chemistry and microbiology.
• Contract Manufacturing Organizations (CMOs): For the production of specialized, high-value active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Amphotericin B, 13-o-Methyl-, (13S)-
CAS No.	944242-31-3
Molecular Formula	C48H75NO18
Molecular Weight	954.1 g/mol
Synonyms	(13S)-13-O-Methylamphotericin B; 13-O-Methylamphotericin B (13S-isomer); 13-Desmethoxy-13-methoxyamphotericin B; 13-Methoxyamphotericin B; Amphotericin B 13-methyl ether; Methylamphotericin B derivative; CAS 944242-31-3
EINECS	Contact for details

Quality Control

Our Amphotericin B, 13-o-Methyl-, (13S)- is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, spectroscopic identification (IR, NMR), and residual solvent analysis to ensure it meets high-purity standards suitable for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. This product is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions to maintain stability. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Yellow to brown powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.