Description

Jnj-38877605 is a potent and selective small molecule inhibitor targeting the c-Met (mesenchymal-epithelial transition factor) receptor tyrosine kinase. This compound is a critical research tool for investigating the role of the HGF/c-Met signaling pathway in oncology and other disease states. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in drug discovery and preclinical development for cancers driven by c-Met dysregulation, such as non-small cell lung cancer, gastric cancer, and glioblastoma.

Application

• Biochemical Research: Used as a selective inhibitor to study c-Met kinase activity, autophosphorylation, and downstream signaling pathways (e.g., MAPK, PI3K/Akt) in cell-free assays.
• Cellular & Molecular Biology: Employed in cell culture studies to investigate the biological effects of c-Met inhibition on tumor cell proliferation, migration, invasion, and apoptosis.
• Preclinical Drug Discovery: Serves as a reference compound or positive control in high-throughput screening (HTS) campaigns and in vitro efficacy studies for novel c-Met inhibitor development.
• Target Validation: A key tool for validating c-Met as a therapeutic target in various in vitro and in vivo xenograft models of human cancers.
• Mechanism of Action Studies: Facilitates research into resistance mechanisms and combination therapy strategies involving c-Met pathway inhibition.

Basic Information

Product Name	Jnj-38877605
CAS No.	943540-74-7
Molecular Formula	C₂₃H₂₀N₆O₂
Molecular Weight	412.45 g/mol
Synonyms	5-[(5-Chloro-2-fluorophenyl)amino]-1-methyl-1H-pyrazolo[3,4-b]pyridine-4-carbonitrile; JNJ-38877605; JNJ 38877605; 1-Methyl-5-[(5-chloro-2-fluorophenyl)amino]-1H-pyrazolo[3,4-b]pyridine-4-carbonitrile; UNII-2Q1V8K2Z8H; 2Q1V8K2Z8H; BDBM50124787; CHEMBL2103875
EINECS	Contact for details

Quality Control

Our Jnj-38877605 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, residual solvents, and other critical parameters is provided with every shipment to guarantee reproducible and reliable research outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.