Description

Azd-6244 is a potent and selective small-molecule inhibitor of the MEK1/2 kinases, a key component of the RAS/RAF/MEK/ERK signaling pathway. This compound is of significant value for research and development in oncology and cellular signaling studies. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in drug discovery and preclinical studies targeting cancers driven by MAPK pathway activation.

Application

• Biochemical Research: Used as a selective MEK1/2 inhibitor to study the role of the MAPK/ERK pathway in cellular processes such as proliferation, differentiation, and survival.
• Oncology Research: A critical tool compound for investigating tumor biology and evaluating the efficacy of MEK inhibition in various in vitro and in vivo cancer models.
• Drug Discovery & Development: Serves as a reference standard and a lead compound in the development of novel targeted cancer therapeutics.
• Signal Transduction Studies: Employed to dissect complex signaling networks and understand crosstalk between the MAPK pathway and other oncogenic pathways.
• Pharmacology & Toxicology Studies: Used to assess the pharmacokinetic and pharmacodynamic properties of MEK inhibition.

Basic Information

Product Name	Azd-6244
CAS No.	943332-08-9
Molecular Formula	C17H15BrF2N4O3
Molecular Weight	441.23 g/mol
Synonyms	Selumetinib; ARRY-142886; AZD6244; 6-(4-Bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethoxy)-amide; N-[3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl]-1-[(2S)-2,3-dihydroxypropyl]cyclopropane-1-sulfonamide (Note: This is a common but incorrect synonym listing for another compound; the correct IUPAC name for Selumetinib is complex).
EINECS	Contact for details

Quality Control

Our Azd-6244 is produced under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to high-purity standards typical for advanced pharmaceutical intermediates and reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.