Description

Ponatinib CAS NO 943319-70-8 is a potent, orally active multi-targeted tyrosine kinase inhibitor. This compound is of significant interest in pharmaceutical research and development due to its targeted mechanism of action against specific oncogenic pathways. It is primarily utilized by pharmaceutical companies, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in the development of novel oncology therapeutics and advanced pharmaceutical intermediates.

Application

• Pharmaceutical Active Ingredient (API): Serves as the core active pharmaceutical ingredient in targeted cancer therapy formulations.
• Oncology Research: Used as a critical reference standard and biochemical tool in preclinical studies for investigating tyrosine kinase inhibition mechanisms.
• Drug Development Intermediate: Employed in the synthesis and process development of next-generation kinase inhibitor drugs.
• Biochemical Assay Standard: Acts as a high-purity control substance in bioanalytical method development and validation for pharmacokinetic studies.
• Academic Research: Utilized in university and institutional labs for studying cell signaling pathways and drug resistance mechanisms.

Basic Information

Item	Details
Product Name	Ponatinib
CAS No.	943319-70-8
Molecular Formula	C29H27F3N6O
Molecular Weight	532.56 g/mol
Synonyms	AP24534; Iclusig; Ponatinib Hydrochloride; 3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide; Benzamide, 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-
EINECS	Contact for details

Quality Control

Our Ponatinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC purity analysis, residual solvent screening, and identity confirmation (IR, NMR, MS) to ensure it meets high-grade pharmaceutical standards. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.