Description

1,2-Pyrrolidinedicarboxylic Acid, 4-(Benzoylamino)-, 1-(1,1-Dimethylethyl) 2-Methyl Ester, (2S,4R)- is a high-purity, stereochemically defined chiral intermediate of significant importance in advanced organic synthesis. This compound is valued for its role as a key building block in the development of complex, biologically active molecules, particularly in pharmaceutical research and development. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing novel compounds with specific three-dimensional architectures.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of potential drug candidates, especially in protease inhibitor research and other therapeutic areas requiring precise stereocontrol.
• Peptidomimetic Research: Serves as a constrained proline analog or scaffold for designing and synthesizing novel peptidomimetics with enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of advanced, stereoselective pesticides and herbicides where specific chirality impacts biological activity.
• Catalyst Ligand Precursor: Can be utilized to develop novel chiral ligands for asymmetric catalysis, enabling more efficient synthesis of enantiomerically pure compounds.
• Academic & Institutional Research: Employed in universities and research institutes for methodological studies in organic chemistry and medicinal chemistry projects.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for CDMOs (Contract Development and Manufacturing Organizations) engaged in producing bespoke, high-value intermediates for clients.

Basic Information

Product Name	1,2-Pyrrolidinedicarboxylic Acid, 4-(Benzoylamino)-, 1-(1,1-Dimethylethyl) 2-Methyl Ester, (2S,4R)-
CAS No.	943134-37-0
Molecular Formula	C19H26N2O5
Molecular Weight	362.42 g/mol
Synonyms	(2S,4R)-1-(tert-Butyl) 2-methyl 4-(benzamido)pyrrolidine-1,2-dicarboxylate; 4-Benzamido-L-proline 1-tert-butyl 2-methyl ester; tert-Butyl (2S,4R)-4-benzamido-2-(methoxycarbonyl)pyrrolidine-1-carboxylate; (2S,4R)-1-Boc-4-benzamido-proline methyl ester; (2S,4R)-4-(Benzoylamino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid methyl ester; (2S,4R)-N-Boc-4-benzamidoproline methyl ester; CAS 943134-37-0
EINECS	Contact for details

Quality Control

Our 1,2-Pyrrolidinedicarboxylic Acid, 4-(Benzoylamino)-, 1-(1,1-Dimethylethyl) 2-Methyl Ester, (2S,4R)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). For long-term storage, consider storing under inert atmosphere to preserve stability, as the compound may be sensitive to moisture and oxidation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (2S,4R)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.